MK2 inhibitor III

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的细胞渗透性 MK2 抑制剂，IC50 为 8.5 nM；不太有效地阻断 MK3 和 MK5（IC50 分别=210 和 81 nM）。

A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM; less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively) and is weak or inactive against several other kinases, including P38 MAPKs; prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells with IC50 of 4.4 uM.

MK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC50 of 4.4 μM.

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MAPK/ERK Signaling

MAPKAPK2 (MK2)

MAPKAPK2 (MK2)

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1186648-22-5

358.4

C21H16N4O ? H2O

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (348.78 mM)

C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O

2-(2-(quinolin-3-yl)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrate

(-20℃)

With Ice Pack

≥ 2 years